Youth-GEMs

Gene and Environment interactions in Mental health trajectories of Youth

OBJECTIVES

Advance the molecular and neurobiological understanding of the interplay between genetic, epigenetic, and environmental factors in driving or preventing the transition from mental health to mental illness in young people
Provide youth and health professionals evidence-based tools and instruments for robust assessment of mental ill-health and for prediction of mental health trajectories
Engagement of young people, patients, and Health Care Professionals (HCPs) in the research framework and participatory medicine for clinical translation and societal valorisation
A lasting privacy-protected, accessible (FAIR) research data infrastructure and an Open Science (OS) framework in the field of youth mental health and functional genomics of the human brain

ROLES

Develop AI-based predictive models of mental illness trajectories and proof-of-concept tools on actionable targets
Perform independent validation analyses in additional samples not included in the initial stage to evaluate the reproducibility of the taxonomy/trajectories within and across site
Gather multi-stakeholder requirements for digital monitoring and assessment of mental health in adolescents

PARTNERS

NO.	INSTITUTION	COUNTRY
1	Universiteit Maastricht	Netherlands
2	Royal College of Surgeons in Ireland	Ireland
3	Max-Planck-Gesellschaft zur Forderung der Wissenschaften Ev	Germany
4	University of Exeter	United Kingdom
5	Universitair Medisch Centrum Utrecht	Netherlands
6	Universitat de Barcelona	Spain
7	King's College London	United Kingdom
8	Cardiff University	United Kingdom
9	University College Dublin, Natinal University of Ireland, Dublin	Ireland
10	Stichting Hogeschool Utrecht	Netherlands
11	Fundació Centre de Regulació Genomica	Spain
12	Tartu Ulikool	Estonia
13	Clinic for Neurology and Psychiatry for Children and Youth	Russia
14	Ab. Acus Srl	Italy
15	Sveuciliste u Splitu Medicinski Fakultet	Croatia
16	Fundación para la Investigación Biomédica del Hospital Gregorio Marañón	Spain
17	University College London	United Kingdom
18	The University of Queensland	Australia